FOIA Sie gedeiht vor allem in Wüsten, Halbwüsten und Steppen von Westasien bis Nordindien, gelegentlich aber auch im Mittelmeerraum. Harmine: Evaluation of its antileishmanial properties in various vesicular delivery systems. [21] isolated six new compounds against HSV-2 virus from crude alkaloids of P. harmala seeds and identified the structures of six new βCs based on HR-ESI-MS data, named pegaharines A–F (15–20) (Figure 2). In conclusion, P. harmala inhibits a variety of pathogenic microorganisms and has great potential in the treatment of infectious diseases and air sterilization. [11] In the same study, the vasorelaxant activity of harman, another active alkaloid of P. harmala, was shown with a mechanism of interaction with the L-type Ca2+ channels and increasing NO release from the endothelial cells so dependent on the presence of external Ca2+. Seed oil had a moderate inhibitory effect on Colletotrichum sp. Known as Syrian rue or wild rue in English, Peganum harmala is a powerful medicine plant that has a lot in common with the Amazonian shamanic vine ayahuasca. [46] mixed oil of P. harmala seeds at concentrations of 50%, 25%, 12.5%, 6.25%, 3.125%, 1.562%, 0.781%, 0.39%, and 0.195% with melted agar and measured the hyphae to study the inhibitory effect of different concentrations of oil to 10 fungi (R. solani, M. phaseolina, Pythium sp. Among them, (−)-peharmaline A (1) (Figure 2) and (+)-peharmaline A (2) (Figure 2) were rare carboline-vasicinone hybrid alkaloid enantiomers with an unknown hybrid dimer system. Bethesda, MD 20894, Web Policies The results showed the strongest inhibition of extract from P. harmala leaves against P. aeruginosa with MICs ranging from 0.25 to 1.0 mg/mL. These findings suggest that harmine, as the main alkaloid of P. harmala, may be useful for treatment of some bone diseases. Peganum harmala can be used with . A rich variety of compounds is the material basis for its broad-spectrum antimicrobial activity. . The methods used in these studies include formalin, hot plate, and writhing tests. Peganum harmala L. is a plant widely used in the traditional Algerian medicine. Peganum harmala is an herbaceous, perennial plant with many reported pharmacological activities: it is carminative, diuretic, antithrombotic and analgesic. Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, 1Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran, 2Veterinary Medicine, Faculty of Agriculture and Veterinary, Shabestar Branch, Islamic Azad University, Shabestar, Iran. It was also found that seed and root extracts showed synergistic effects when combined with neomycin, colistin, and carbenicillin. 2853, Salmonella sp. Harmine at high doses increased the BDNF (Brain-derived neurotrophic factor) protein level, which is decreased in depressive conditions, while imipramine, a common anti-depression drug, had no such effect. These alkaloids significantly inhibited the enzyme via both transcriptional and posttranslational mechanisms in a concentration-dependent manner. Antioxidant, Antimicrobial, Phytochemical and FTIR Analysis of Peganum ... El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. Before harmala extracts and four systemic commercial fungicides were initially investigated for their in vitro toxicity . [23,56] Various authors have reported cytotoxicity of P. harmala on tumor cell lines in vitro and in vivo. Peganum harmala L., a perennial herb that belongs to the Zygophyllaceae family, is distributed in the Mediterranean region of Europe, Central Asia, and southern South America. In another experiment using the MTT assay to determine the inhibition of MDR E. coli by harmine and its derivatives, a number of cell ruptures and cell debris were observed in the treated E. coli. The extracts were subjected to silica gel column chromatography, ODS column chromatography, MCI resin, and other technologies, and a new compound was found and named N-[3-(2-amino-4-methoxyphenyl)-3-oxopropyl] acetamide (14) (Figure 2). Our aim in preparing this paper was to show the traditional usage and previously confirmed pharmacological effects of P. harmala as one of the most well-known medicinal plants in Iran and to illustrate it's potential to be used as a novel source for the development of new drugs based on the most recent associated studies. The toxicity assessment of extract of Peganum harmala L. seeds in ... Lamchouri F, Settaf A, Cherrah Y, El Hamidi M, Tligui N, Lyoussi B, et al. Nucleic acid is the main information molecule of cells, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Chemical Composition, Antibacterial and Phytotoxic Activities of ... The extract reduced viral mRNA expression and inhibited viral protein synthesis in a dose-dependent manner, with no effect on hemagglutination inhibition and virucidal activity. It was found that the viral production was significantly reduced, and harmine affected viral replication at early and later stages [67]. harmala. The MFC against C. tropicalis was 0.125 mg/mL. Apostolico et al. 7987, Clostridium sp. [64] Other effects of the plant extract such as anti-proliferative effect on Leukemic cell lines,[65] inhibitory action on the metastasis of melanoma cells, inducing apoptosis in melanoma cells,[66] tumor angiogenesis inhibition,[13] and binding to RNA[61] have also been reported by various authors. 82173885), the National Natural Science Foundation of China and Xinjiang Uyghur Autonomous Region of China (no. Some of these alkaloids such as harmaline, harmine, and norharmane are also endogenous compounds present in the body and since they have been found in high plasma concentrations in alcoholics,[27] drug addicts,[28] smokers,[29] and patients with Parkinson's disease,[30] they are thought to be crucially involved in various central nervous system (CNS) problems. Dried capsules – mixed with other ingredients – are burnt as a charm against “the evil eye” among Iranians. [58] Another study indicated that harmine and its derivatives have inhibitory effect on human Topoisomerase I activity but no effect on Topoisomerase II. 4377, and Salmonella sp. Mohagheghzadeh A, Faridi P, Shams-Ardakani M, Ghasemi Y. The antibacterial effects of P. harmala have been demonstrated in many Gram-positive and Gram-negative bacteria. government site. The conidial suspension of plant pathogenic fungus P. digtiatum was treated with 1 mM harmol. Hajji et al. PLGA/PEG nanoparticles loaded with cyclodextrin-. P. harmala seeds smoke can act as an air disinfectant to reduce the concentration of bacteria in air [40]. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. It was found that there was inhibitory activity of P. harmala against Gram-negative bacteria (MIC range of 4–8 mg/mL) and the chloroform extract from P. harmala leaves. Peganum harmala L. is a plant widely distributed in the Mediterranean region. Antibacterial activity of different parts of, Omar S.S. Inhibitory effect of nisin and some of plant extracts against growth of. Khaliq T, Misra P, Gupta S, Reddy KP, Kant R, Maulik PR, et al. Various medical properties of P. harmala were collected from important TIM references and added to scientific reports . Bethesda, MD 20894, Web Policies These results herald the bright prospect of P. harmala as a natural source of next-generation medicines, and also lay the foundation for further elucidation of its therapeutic mechanisms, thus, revealing the relationships among the clinical uses, chemical components, and biological activities of P. harmala. In an in vitro study by Li et al., budding yeast was used as a model to investigate the anti-tumor activity of P. harmala. It was speculated that this may be due to the differences in the growth environment of P. harmala in different countries, resulting in different percentages of secondary metabolites of plants such as oxygen-containing monoterpenes, sesquiterpenes, and oxygen-containing sesquiterpenes. Muhaisen H.M., Ab-Mous M.M., Ddeeb F.A., Rtemi A.A., Taba O.M., Parveen M. Antimicrobial agents from selected medicinal plants in Libya. It also inhibited the kinase activity of Cdk2/CyclinA (a member of the cyclin family) in vitro. In recent years, epidemics have become the greatest threat to human health and plant quality. The suggested mechanism for this property is the inhibitory effect of harmaline on protein kinase C (PKC) action of the parasites. [19], two pairs of new alkaloid glycoside dimorphisms (9–12) (Figure 2) and a new enantiomer (13) (Figure 2) were identified in the ethanol extracts of P. harmala seeds. 2007 4 ). After removing organic solvents, chitosan nanoparticles were used to encapsulate the extracts and forsythia essential oil (NCE), and the activity of encapsulated nanoparticles against Alternaria spp. The concentrate was re-extracted with n-hexane and ethyl acetate. P. harmala has been proved to have significant anti-parasitic activity. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, antimicrobial, antibacterial, antifungal, antiviral, genus. The results showed that P. harmala extracts inhibited the growth of these bacteria with MICs of 0.8, 1.2, 0.9, 1.0, and 0.9 mg/mL, respectively. The chemical composition of essential oils of P. harmala seeds from five different regions of Northern Africa (Algeria, Egypt, Libya, Morocco and Tunisia) was studied by GC and GC-MS . A growing number of studies have shown superior inhibition of P. harmala against a wide range of microorganisms, and the antimicrobial mechanisms have also been identified. Rahimi-Moghaddam P, Ebrahimi SA, Ourmazdi H, Selseleh M, Karjalian M, Haj-Hassani G, et al. Peganum Harmala, the "Ayahuasca" of North Africa and Eurasia Chen D., Su A., Fu Y., Wang X., Lv X., Xu W., Xu S., Wang H., Wu Z. Harmine blocks herpes simplex virus infection through downregulating cellular NF-kappaβ and MAPK pathways induced by oxidative stress. Artemisinin: A wonder drug from Chinese natural medicines. Six new βCs were identified, i.e., pegaharmines F–K (3–8) (Figure 2). Peganum harmala (P. harmala) belongs to the family Zygophyllaceae, and is utilized in the traditional medicinal systems of Pakistan, China, Morocco, Algeria, and Spain to treat several chronic health disorders. The removal rate of bacteria in air after 5 g of seeds in residential areas produced smoke for 5 min reached a maximum of 71.4%. [43], It is concluded that P. harmala and its alkaloids could probably be used for the control of antibiotic resistant isolates of bacteria.[54]. Intercalation of several carbolines into eukaryotic DNA has also been reported by many authors. The .gov means it’s official. The antimicrobial activity and antimicrobial mechanism of βCs, such as harmine, were studied to provide a theoretical basis for the development of potential antibacterial drugs. Novel carboline alkaloidfrom. In case of the seed extract the inhibitory effect was reversible and competitive with an IC50 of 27 μg/l and it was mostly attributed to harmaline and harmine. Based on these observations, it was suggested that this inexpensive and readily available plant combination formulation could be used on farms. Scientific Name(s): Peganum harmala L. Common Name(s): African rue, Harmal shrub, Harmel, Isband, Ozallalk, Steppenraute, Syrian rue, Wild rue Medically reviewed by Drugs.com. The positive control oxytetracycline (200 ppm) showed the highest antibacterial activity inhibition zone, which was 24.70 mm. P. harmala also possesses noticeable nauseant[71] and emetic[7,72] effects. Die Steppenraute oder Harmelraute (Peganum harmala), im deutschen Sprachraum auch Harmalkraut, Syrische Steppenraute oder Afrikanische Raute genannt, ist eine Pflanzenart aus der Gattung Peganum innerhalb der Familie der Nitrariaceae. Alkaloids from the seeds of. The methanol extract had the strongest activity. In an in vitro study desoxypeganine, one of the P. harmala alkaloids, dose-dependently decreased ethanol consumption in female Alko alcohol rats with no effect on food and fluid consumption. Activities of extract and constituents of. The names of the compounds 9–12 are (S)- and (R)-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (9,10), (S)- and (R)-vasicinone β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (11,12). Mikaili P, Sharifi M, SHayegh J, Sarahroodi SH. The authors declare no conflict of interest. F. alnus and P. harmala showed strong antioxidant effects attributed to the polyphenolic composition of leaves and reduction of reactive oxygen species (ROS) accumulation. [3] Ethanol and chloroform extracts of P. harmala showed protective effects against thiourea-induced carcinogenicity by normalization of neuron-specific enolase and thyroglobulin levels in animal models. with the inhibition from 5.19% to 42%. Apostolico I., Aliberti L., Caputo L., De Feo V., Fratianni F., Nazzaro F., Souza L.F., Khadhr M. Chemical composition, antibacterial and phytotoxic activities of, Tabrizizadeh M., Kazemipoor M., Hakimian M., Maleksabet M., Kazemipoor M., Zandi H., Pourrajab F., Che C.T., Cordell G.A. [49] tested the anti-TMV activities of β-carboline, dihydro-β-carboline, and tetrahydro-β-carboline alkaloids and their derivatives using the Ishida’s method. Infected pigeons were completely recovered after 3 days of treatment with alkaloids but they were not completely recovered with metronidazole. It was found that the mycelium growth rate of most fungi decreased when treated with water extract and methanol extract, and the seed extract had the highest activity. [63] collected Trichomonas gallinae from pigeons using the wet mount method, cultured it in trypsin/yeast extract/maltose (TYM) medium on multiwell plates with P. harmala alkaloid extract, metronidazole, harmine, and harmaline at concentrations of 5, 10, 15, 20, 30, 50, and 100 μg/mL, to determine the MICs. Antioxidant and Anti-Inflammatory Effects of Peganum harmala ... - MDPI Clinical Overview Use. Kahouaji MS. Harmine is the most studied among these naturally occurring alkaloids. Molecules | Free Full-Text | Antibacterial, Antifungal, Antiviral, and ... [84] P. harmala methanolic extract has showed teratogenic effects in female rats. 3. The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Blaser M.J. Mirza R., Azeem M., Qaisar U. It was suggested that P. harmala or the ingredients could play a significant role in drug development for controlling bacteria. Shahverdi et al. Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasari W, Widyawaruyanti A, et al. Curti V., Capelli E., Boschi F., Nabavi S.F., Bongiorno A.I., Habtemariam S., Nabavi S.M., Daglia M. Modulation of human miR-17-3p expression by methyl 3-O-methyl gallate as explanation of its in vivo protective activities. Stohler R, Hug I, Knoll B, Mohler B, Ladewig D. Initial results with withdrawal treatments of male and female participants in the diversified Janus opiate prescription project in Basel. By Giorgio Samorini - March 1, 2019 [56,61] The alkaloid-DNA binding affinity was ordered as harmine >harmalol >harmaline >harmane >tryptoline. In addition, it was concluded that the selection of compounds that act synergistically with P. harmala alkaloids had great potential in the treatment of diseases caused by P. vulgaris. Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, et al. [17] conducted a study on the chemical composition of P. Except for the petroleum ether extract of P. harmala leaves without resistance, there was anti-HCMV activities of all the other extracts. Since there have been many reports of intoxications following ingestion of specific amounts of P. harmala seeds, care should be taken by scientists and clinicians regarding usage of this plant for therapeutic purposes until adequate studies confirm the safety and quality of the plant. Antitumour principles from. Histological studies showed that P. harmala extracts caused a severe cytotoxicity on the epithelial cells of the midgut resulting in marked vacuolization of the cytoplasm and a large intercellular space. African-rue has long been used as a dye plant and was imported into New Mexico in 1928 for "Turkish Red" dye (Guclu and Ozbek 2007 3 ). Hamden K, Silandre D, Delalande C, Elfeki A, Carreau S. Protective effects of estrogens and caloric restriction during aging on various rat testis parameters. Merzouki A, Ed-derfoufi F, Molero Mesa J. Hemp (Cannabis sativa L.) and abortion. The emergence and variation of new pathogens and the emergence of drug resistance pose a huge threat to humans, and therefore, there is an urgent need for effective drugs to change this situation. Zinner S.H. [61] treated coccidiosis chicken with the methanol extract of P. harmala seeds at concentrations of 200 mg/L (PH-200), 250 mg/L (PH-250), and 300 mg/L (PH-300) in drinking water. Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A study on the antitumoral and differentiation effects of. [34] All of these effects represent an idea that P. harmala and its derivatives could be used for treatment of mood disorders and are potent alternatives for current anti-depression drugs. Infectious diseases have always been the number one enemy threatening health and well-being. Wu et al. Akhtar MS, Iqbal Z, Khan MN, Lateef M. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo±Pakistan subcontinent. The water-soluble seed extract could inhibit the spore germination of F. oxysporum. [6,7] In an in vitro study, intrapretoneal administration of three different extracts of P. harmala at a dose of 50 mg/kg body weight induced sympthoms such as: Abdominal writhing, body tremors and slight decrease in locomotor activity,[21] while oral administration of these extracts showed no toxicity. Encapsulated with forsythia essential oil, the total inhibitory concentration decreased to 200 ppm. Soltani J., Aliabadi A.A. Antibacterial effects of several plant extracts and essential oils on. The alkaloids of P. harmala are also shown to have anti-platelet aggregation effects. with inhibition rates of mycelial growth ranging from 56% to 82%, followed by F. solani f. sp. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPAR sssssgamma expression. Interaction of β-carboline alkaloids with RNA. From the current studies, it can be seen that there are many antifungal studies on P. harmala, which have revealed that there is good antifungal activity of P. harmala. In particular, the in vitro and in vivo activities of harmalan (60.3%) and tetradydroarmane (59.5%) at 500 μg/mL were much higher than that of ribavirin (38.5%). It was shown in another in vitro study that the extract of P. harmala has the ability to inhibit catechol-O-methyltransferase and thereby the methylation of catecholamines with a mixed type mechanism. The strong inhibitory effect of the root extract was only due to harmine and the IC50 was calculated as159 μg/l. Peganum spp.: A Comprehensive Review on Bioactivities and Health ... It was also found that carbon C3C4 double-bond and 7-methoxy group of harmine plays an important role in these processes. Yalcin D, Bayraktar O. Inhibition of catechol-O-methyltransferase (COMT) by some plant-derived alkaloids and phenolics. [38] also tested the in vitro inhibitory effect of seven plant extracts including P. harmala on bacteria using a paper disc diffusion method and in vivo inhibitory effect using pot experiments. Another study also illustrated this point [43]. For example Proteus vulgaris and Bacillus subtilis appeared to be very sensitive to harmine. Therefore, there is an urgent need for new antimicrobial drugs to address diseases caused by drug-resistant microorganisms. In recent years, numerous studies have shown that more and more natural products of plants have special biological activities as natural antibiotics that play important roles in prevention, treatment, and reducing disease prevalence [8,9,10,11], such as the artemisinin extracted from herb Artemisia annua L. with antimalarial effect [12]. Jahaniani F, Ebrahimi SA, Rahbar-Roshandel N, Mahmoudian M. Xanthomicrol is the main cytotoxic component of. It was found that root extract had better antibacterial activity against Gram-positive bacteria than seed extract.
Waipu Tv Anmelden Aktivierungscode Eingeben,
Resource Materialspanoramaimagesicons Ui Globe Svg Failed To Load,
Push Nachrichten Von Webseiten Deaktivieren Chrome,
3d Stadium Creator,
Atu Kostenvoranschlag Unfall,
Articles P
